Antimicrobial resistance (AMR) in gram-negative bacteria is genetically very complex. It concerns many different resistance genes and within these genes many different variants exist. Individual resistance genes or variants may be present in a wide range of gram-negative bacteria or may be specific for a single species. Local epidemiology may also differ significantly between various geographical regions. Check-Points employs various technology platforms for testing of AMR gram-negative bacteria depending on the clinical application. For clinical diagnostics the following application may be relevant:
- Screening of individuals suspected of carrying AMR gram-negatives for infection prevention;
- Testing individuals infected with gram-negative bacteria for increased resistance against β-lactams;
- Genotypic confirmation of gram-negative bacteria with elevated resistance in culture-based susceptibility testing;
- Genotypic profiling of single bacteria for epidemiological typing.